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The use of modified polymeric polyhipe as an immobilized cell matrix

Jimat, Dzun Noraini and Azmi, Azlin Suhaida (2011) The use of modified polymeric polyhipe as an immobilized cell matrix. In: Current research and development in biotechnology engineering at IIUM. IIUM Press, Kuala Lumpur, pp. 297-305. ISBN 9789674181444

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Utilization of modified-polyHIPE polymer matrix in the immobilization cell system is probably can substitute conventional cell matrix. The confined microenvironment was designed to promote the bacterium growth and its metabolic activity. The applied forced-flow seeding technique yielded a more uniform distribution of cells within the polymeric support, which also helps to improve nutrient transport. This also prevents significant growth of cells around the outer surface of matrix. The microstructure of the matrix with respect to its physico-chemical characteristics, which include appropriate pore and interconnect sizes as well as surface chemistry (i.e. hydrophobic, hydrophilic), are very important with respect to the flow of nutrients and waste material and also for cell migration. As a result, the developed immobilized matrix can be performed effectively and essential in the area of bioprocess development specifically for microbial fermentations.

Item Type: Book Chapter
Additional Information: 3891/20993
Uncontrolled Keywords: polyHIPE polymer matrix, immobilization cell, microenvironment, forced-flow seeding, physico-chemical characteristics
Subjects: T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User: Sakinah Kamaludin
Date Deposited: 05 Jul 2012 12:19
Last Modified: 05 Jul 2012 12:19
URI: http://irep.iium.edu.my/id/eprint/20993

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