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Correlation of serum insulin like growth factor-I with retinopathy in Malaysian pregnant diabetics

Adzura, Salam and Muhaya, M and Zaleha, A. M. and Sharifa Ezat, W.P (2011) Correlation of serum insulin like growth factor-I with retinopathy in Malaysian pregnant diabetics. International Journal Of Ophthalmology, 4 (1). pp. 69-72. ISSN 16725123

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Abstract

AIM: To study the association of serum insulin-like growth factor-I (IGF-I) with diabetic retinopathy. ·METHODS: Serum IGF-1 levels were measured in 25 pregnant diabetic patients and 25 pregnant non-diabetic patients who were matched for age, ethnicity, parity and period of gestation. Fundus examination was performed in both groups at 28, 32 and 36 weeks of gestation. ·RESULTS: The serum IGF-I level was significantly elevated in pregnant diabetics compared to pregnant non-diabetics (366± 199滋g/L 184± 89滋g/L, ( =0.0001) at 24 weeks, 535± 251滋g/L 356± 89滋g/L, ( =0.007) at 32 weeks and 404± 166滋g/L 264± 113滋g/L, ( =0.003) at 36 weeks of gestation). The pregnant diabetics with established diabetes had significantly higher IGF-1 level than gestational diabetes at 28, 32 and 36 weeks of gestation. The serum IGF-I level in pregnant diabetics with retinopathy was significantly higher than in those without retinopathy at all periods of gestation.

Item Type: Article (Journal)
Additional Information: 3639/20734
Uncontrolled Keywords: diabetic retinopathy; pregnancy; serum IGF-1 level
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Ophthalmology
Depositing User: Mrs Maznah Zakaria
Date Deposited: 21 Feb 2012 14:23
Last Modified: 27 Jun 2013 09:44
URI: http://irep.iium.edu.my/id/eprint/20734

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