Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines

Sahidin, and Nakazibwe, Sauba and Taher, Muhammad and Kumar Saxena, Anil and Arief Ichwan, Solachuddin Jauhari and Ardiyansyah, (2011) Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines. Australian Journal of Basic and Applied Sciences, 5 (8). pp. 47-51. ISSN 1991-8178

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Abstract

This study was designed to determine antiproliferative properties of curcusone B from the stem bark of Jatropha curcas on cell lines K562 (chronic myelogeneous leukemia), and H1299 (human non-small cell lung carcinoma). Cells were cultured in the presence of curcusone B at various concentrations and the percentage of cell viability was evaluated by trypan blue exclusion method and MTT assay. Curcusone B showed significant dose-dependent inhibition of cell proliferation of K562 and H1299 cell lines with an IC50 of 6 μg/mL and 15.0 μg/mL, respectively. The findings suggested that the curcusone B had strong antiproliferation which was dose dependent and may have potential as an anticancer agent.

Item Type:	Article (Journal)
Additional Information:	5209/20337
Uncontrolled Keywords:	Jatropha curcas, Curcusone B, Antiproliferative, cell culture
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User:	Mrs Maznah Zakaria
Date Deposited:	20 Feb 2012 10:41
Last Modified:	11 Mar 2014 08:29
URI:	http://irep.iium.edu.my/id/eprint/20337

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