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Blood pressure variability in patients with diabetes mellitus

Mokhtar, Rafidah Hanim and Ayob, Azizi and Mohd Noor, Noriah (2010) Blood pressure variability in patients with diabetes mellitus. Asian Cardiovascular and Thoracic Annals , 18 (4). pp. 344-348. ISSN 0218-4923

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Reduced arterial compliance in patients with diabetes mellitus has been shown in several studies, but it has not been significantly associated with either atherosclerosis or vessel wall thickness. Blood pressure variability is still poorly explored in diabetic patients. The aim of this study was to compare blood pressure variability and arterial compliance in patients with type 2 diabetes mellitus and controls matched for sex, age, and weight. Arterial compliance was measured and noninvasive 24-h ambulatory blood pressure monitoring was performed in 18 diabetic patients and 18 controls. There was significantly higher 24-h systolic blood pressure variability (17.7 ± 6.8 vs. 14.6 ± 2.6 mm Hg), diastolic blood pressure variability (15.6 ± 7.1 vs. 11.4 ± 3.1 mm Hg), and mean arterial blood pressure variability (14.8 ± 7.0 vs. 11.1 ± 2.9) in diabetic patients. Systolic, diastolic, and mean arterial blood pressure variability was significantly higher during daytime but not night time in diabetic patients compared to controls. Diabetic patients also had significantly reduced small artery compliance, but no differences in large artery compliance, cardiac output, or systemic vascular resistance. The findings suggest that hyperglycemia may affect the compliance of the vascular system, resulting in high blood pressure fluctuations.

Item Type: Article (Journal)
Additional Information: 3960/19015
Uncontrolled Keywords: Ambulatory; Atherosclerosis; Blood Pressure; Blood Pressure Monitoring; Diabetes Mellitus; Hemodynamics; Type 2
Subjects: R Medicine > RC Internal medicine
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Kulliyyah of Pharmacy
Depositing User: Prof Noriah Mohd Noor
Date Deposited: 14 Feb 2012 15:18
Last Modified: 12 Nov 2016 12:03
URI: http://irep.iium.edu.my/id/eprint/19015

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