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Parkinsonism complicating acute organophosphate insecticide poisoning

Hashim, Hasnur Zaman and Wan Musa, Wan Rosmaiza and Chai, Soon Ngiu and Wan Yahya, Wan Nafisah and Hui, Jan Tan and Ibrahim, Norlinah (2011) Parkinsonism complicating acute organophosphate insecticide poisoning. Annals Academy of Medicine Singapore, 40 (3). pp. 150-151. ISSN 0304-4602

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Organophosphate insecticides have a triphasic effect on the central nervous system, namely acute cholinergic crisis, intermediate syndrome and delayed polyneuropathy. Although acute organophosphate poisoning is relatively common, case reports describing parkinsonism as a neurological complication following an acute intoxication are limited. 1 We report a case of parkinsonism noted on day 24 of admission following an acute severe organophosphate poisoning which was successfully treated with benzhexol and levodopa. Previously, response to levodopa was reported to be poor in 3 patients studied by Bhatt et al 1whereas amantidine, dopamine agonist and bipiriden have been shown to be helpful. 2To the best of our knowledge, this is the fi rst case of parkinsonism complicating organophosphate poisoning which responded to levodopa and benzhexol therapy.

Item Type: Article (Journal)
Additional Information: 5220/18676
Uncontrolled Keywords: parkinsonism, complicating, acute
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Medicine
Depositing User: Nur' Aini Abu Bakar
Date Deposited: 14 Mar 2012 10:24
Last Modified: 14 Mar 2012 10:24
URI: http://irep.iium.edu.my/id/eprint/18676

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