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The vascular protective effects of polyphenols.

Md. Jaffri, Juliana (2011) The vascular protective effects of polyphenols. In: Current Issues in Pharmacy. IIUM Press, International Islamic University Malaysia, pp. 196-214. ISBN 9789674180195

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Polyphenols have been proven, both in animal and human studies to be beneficial as vascular protective agents. The effect is claimed to be related to the compound antioxidative properties. This effectively blunts the vasoconstriction process, reported to be due to the excessive generation of reactive oxygen species, as observed in many in vitro studies using isolated arteries. The mechanism ofthe vasodilation process invo Ived the endothelium, or it could also be endothelium-independent. In many studies the fornler seemed to be the main pathway. The role of nitric oxide in endothelium-dependent vasodilation activity of the polyphenols is attributed to its protective effect on the soluble gas from deterioration by ROS, as it is capable of neutralizing the radicals. Polyphenols has also been proven to stimulate endothelial nitric oxide synthase to produce more NO, and hence improve vasorelaxation

Item Type: Book Chapter
Additional Information: 4162/18506
Uncontrolled Keywords: Vascular protective effects, polyphenols
Subjects: R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr Juliana Md Jaffri
Date Deposited: 27 Aug 2012 15:56
Last Modified: 27 Aug 2012 15:57
URI: http://irep.iium.edu.my/id/eprint/18506

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