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Histopathological evaluation of skin wound in rabbits treated by systemic dexamethasone

Kashmola, Muhanad Ali Hamdon and Mustafa, Nazih Shaban and Mustafa Al-Ahmad, Basma Ezzat and Al-Ani, Imad Matloub Dally (2011) Histopathological evaluation of skin wound in rabbits treated by systemic dexamethasone. In: 20th Scientific Conference of Microscopy Society of Malaysia & 21st Annual General Meeting, 20-22 Dec 2011, Permaisuri Resort, Port Dickson.

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Abstract

Background: Healing of all damaged tissues including skin wounds have an identical pattern and depends on numerous intrinsic and extrinsic factors, one of these factors is cortisone hormone. Aim of study: The present study was designed to show the effect of dexamethasone on skin wound healing. Materials and methods: Twelve rabbits were used, experimental group (7 rabbits) administrated 4 mg dexamethasone ten days prior to skin incision and control group (5 rabbits) had got skin incision. Biopsies were taken from two groups for histopathological evaluation. Results: control group shows proper wound healing includes epithelial growth migration that brought the wound edges to be close. Granulation tissue underneath the epithelium show to fill the incision gap represented by collagen fibers and fibroblast cells. The experimental group shows failure of epithelial wound edges to close and to be approximately in contact with absence of rete ridges. The main bulk tissue filled the incision gap is thick granulation tissue. Inflammatory cell with congested blood vessels can be detected. Conclusion: Prolonged use of dexamethasone or misuse of this drug impaired wound healing.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 5756/14528
Uncontrolled Keywords: light microscope, skin, healing, Dexamethasone
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Dentistry
Kulliyyah of Medicine
Depositing User: Assoc. Prof. Dr. Muhannad Ali Kashmoola
Date Deposited: 18 Apr 2013 09:26
Last Modified: 18 Dec 2015 11:06
URI: http://irep.iium.edu.my/id/eprint/14528

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