Potential beta-glucosidase inhibitor from Malaysian medical plants

Ahmad Barkat, Anumsima and Jamal, Parveen and Amid, Azura (2009) Potential beta-glucosidase inhibitor from Malaysian medical plants. In: Malaysian International Conference on Trends in Bioprocess Engineering (MICOTriBE 2009), 12-13 December 2009, PWTC, Kuala Lumpur.

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Abstract

Diabetes is one of the chronic diseases affecting worldwide population. Presently, there is a growing interest in herbal remedies due to the side effects associated with the use of insulin and oral hypoglycaemic agents for diabetic patient. Therefore an investigation is required in a bionetwork rich and industrially-developed country like Malaysia to use alternative approaches to treat diabetics, such as plant based medicine. In this study, forty types of Malaysian antidiabetic plants were examined on the basis of their uses in traditional medicines throughout Southeast Asia, to develop an understanding of the distribution and to give an assessment of the diversity present in the selected plants. Extracts of all 40 species of Malaysian medicinal plants were examined for �-glucosidase inhibition using an in-vitro model. Most of the plants showed varying degree of inhibitory activity (%) but Centella asiatica had the maximum percentage of �-glucosidase inhibitory activity (99.03%) while the second best is Morinda citrifolia with 96.37% inhibitory activity. Another two potential plants which gave higher inhibitory activity were Cucumis sativus (93.95%) and Euphorbia tircalli L. (90.56%). These potential plants with �-glucosidase inhibitory activity can be a hope for millions for treatment of diabetes and will also help in reducing the dependence on synthetic drugs in the future.

Item Type:	Conference or Workshop Item (Full Paper)
Uncontrolled Keywords:	�-glucosidase, Centella asiatica, Morinda citrifolia, Cucumis sativus,Euphorbia tircalli L.
Subjects:	R Medicine > R Medicine (General) T Technology > TP Chemical technology > TP248.13 Biotechnology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Biotechnology Engineering
Depositing User:	Prof.Dr. Parveen Jamal
Date Deposited:	14 Jan 2012 08:33
Last Modified:	14 Jan 2012 08:33
URI:	http://irep.iium.edu.my/id/eprint/13894

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