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Study of β2-Adrenergic Receptor Polymorphisms among Hypertensive

Atia, Ahmed El Badri and Ku Zaifah, Norsidah and Abdullah, Nor Zamzila and Mokhtar, Rafidah Hanim and Draman, Samsul and Md Aris, Mohd Aznan and Abdul Rahman, Rashidah and A. Talib, Norlelawati (2010) Study of β2-Adrenergic Receptor Polymorphisms among Hypertensive. In: 3rd IIUM-iCAST International Conference on Advancement in Science and Technology, 26-29 November 2010, Kuantan, Pahang, Malaysia. (Unpublished)

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Abstract

Polymorphisms within Beta2-adrenergic receptor (β2AR) gene have been repeatedly linked to hypertension. Among the β2AR polymorphisms detected, Arg16Gly and Gln27Glu codons were considered the two most important variations. Arg16Gly especially, has been found to be significantly associated with hypertension in Caucasian and black subjects. The amino acid substitution at this codon may lead to abnormal regulation of β2AR activity. The aim of the present study was to assess the association between B2AR polymorphisms and hypertension. This case-control study consisted of 100 unrelated subjects (50 hypertensive and 50 matched normal controls). Arg16Gly and the Gln27Glu polymorphisms were analysed by polymerase chain reaction- restriction fragment length polymorphism assay. Results: There were no significant evidence of association in allelic and genotypes distribution of Arg16Gly and Glu27Gln with elevated blood pressure and hypertension. These findings suggest that the variation within codon 16 and 17 of β2AR gene were unlikely to confer genetic susceptibility for hypertension in our population samples.

Item Type: Conference or Workshop Item (Poster)
Additional Information: 3746/13747
Uncontrolled Keywords: β2-adrenergic receptor, single nucleated polymorphism, hypertension, blood pressure.
Subjects: R Medicine > R Medicine (General)
R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Basic Medical
Depositing User: Dr Nor Zamzila Abdullah
Date Deposited: 08 Mar 2012 12:25
Last Modified: 16 Jun 2017 09:48
URI: http://irep.iium.edu.my/id/eprint/13747

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