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Esophageal surface cells in Non-erosive Reflux Disease (NERD): Scanning electron microscopic study

Myint, Yi Yi and Tun, Ye (2011) Esophageal surface cells in Non-erosive Reflux Disease (NERD): Scanning electron microscopic study. In: 20th Scientific Conference of Microscopy Society of Malaysia , 20th to 22nd December 2011, Permaisuri resort, Port Dickson. (Unpublished)

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Abstract

Dilated intercellular spaces (DIS) in prickle cell layers are considered as early signs of acid damage to the esophageal epithelium. In order to enter the mucosal intercellular spaces, acid and pepsin have to penetrate the intercellular adhesion sites of the most superficial epithelial cells. The aim of this study is to explore cellular attachments in most superficial esophageal cells of non- erosive (NERD) patients. The study group included 8 (NERD) patients and 5 normal controls. Specimens were routinely processed for SEM. The nature of cellular attachment and intercellular spaces between superficial cells of esophageal mucosa were viewed by SEM. Our results showed that cellular attachments in the superficial cells differ significantly (p value 0.007) among the normal controls and patients with NERD (Chi-Square test, p <0.05 was considered to be statistically significant). Our findings supported the concept of abnormal tissue resistance in pathogenesis of NERD patients. Key words: Non-erosive Reflux Disease (NERD), Dilatation Intercellular spaces (DIS), scanning electron microscopy (SEM)

Item Type: Conference or Workshop Item (Speech/Talk)
Additional Information: 3635/13252
Uncontrolled Keywords: Non-erosive Reflux Disease (NERD), Dilatation Intercellular spaces (DIS), scanning electron microscopy (SEM)
Subjects: Q Science > QM Human anatomy
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Basic Medical
Depositing User: Dr Yi Yi Myint
Date Deposited: 15 Feb 2012 11:01
Last Modified: 21 Jun 2017 14:24
URI: http://irep.iium.edu.my/id/eprint/13252

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