Simulation of serpentine microfluidic channel for portable virus detection system

Jazmi, Ahmad Akmal and Muhamad Atan, Muhammad Khairul Faisal and Ab. Rahim, Rosminazuin and Md Ralib @ Md Raghib, Aliza 'Aini and Mohd Mansor, Ahmad Fairuzabadi and Nordin, Anis Nurashikin (2025) Simulation of serpentine microfluidic channel for portable virus detection system. In: 2025 IEEE Regional Symposium on Micro and Nanoelectronics (RSM), 08-09 September 2025, SWISS GARDEN HOTEL MELAKA.

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Abstract

This paper presents a comprehensive simulation study of a 3D-printed microfluidic system designed for virus detection using Loop-Mediated Isothermal Amplification (LAMP) at a constant temperature of 65°C for a duration of 35 minutes. To enhance portability and reduce the dependency on bulky thermal cycling equipment required in conventional PCR methods, a serpentine microchannel geometry was designed using AutoCAD and analyzed in finite element simulation. The simulation integrates laminar flow and heat transfer physics to evaluate critical parameters including velocity distribution, volume flow rate, pressure drop, Reynolds number, and temperature profile. Results show stable laminar flow with a low Reynolds number (Re = 0.175), minimal secondary flow effects (Dean number = 0.107), and consistent volume flow rates around 262 μL/hr within 35 minutes. Thermal analysis indicates effective heat transfer with uniform temperature distribution along the channel. These findings validate the model’s suitability for isothermal nucleic acid amplification and support its application in low-cost, point-of-care diagnostic devices.The simulated design can be fabricated using 3D-printing technology for a portable virus detection system.

Item Type:	Proceeding Paper (Plenary Papers)
Uncontrolled Keywords:	Finite element simulation, microfluidic, velocity, volume flow rate, pressure, temperature, Reynold number, Laminar flow
Subjects:	T Technology > TK Electrical engineering. Electronics Nuclear engineering > TK7800 Electronics. Computer engineering. Computer hardware. Photoelectronic devices
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Engineering > Department of Electrical and Computer Engineering Kulliyyah of Engineering
Depositing User:	Dr. Ahmad Fairuzabadi Mohd Mansor
Date Deposited:	25 May 2026 15:40
Last Modified:	25 May 2026 15:40
Queue Number:	2026-05-Q3555
URI:	http://irep.iium.edu.my/id/eprint/129135

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