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Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis

Jaafar, Khairul Azhar and Hasmoni, Mohamed Hadzri and Abdul Rashid, Mohd Amran and Md Ralib @ Md Raghib, Ahmad Razali and H, Nora and Satwi, Sapari (2008) Hepatic steatosis among chronic hepatitis C infected patients selected for treatment - a retrospective analysis. Hepatology International, 2 (Supp). S513-S514. ISSN 1936-0533

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Abstract

Hepatic steatosis is a common feature of chronic hepatitis C (CHC). It is caused directly by the virus (genotype 3)or host metabolic factors. We analyzed liver biopsy results among all patients selected for the treatment. Methods: We retrospectively looked into CHC patients selected for treatment from 2005 - 2007,Kuantan Hospital, Malaysia. Fifteen patients were identified between the ages of 19 - 58 years. Blood results for HCV RNA viral load, genotyping, lipid profile, liver biopsy (Ishak et al score) and body mass index (BMI) were documented pretreatment. Results: Seven patients were genotype 1, 6 patients were genotype 3 and 1 patient each for genotype 2 and 6 respectively. Majority of patients had mild hepatic steatosis, 60% (n=9/15) pretreatment and highest were among genotype 1, 33.3% (n=5/15), followed by genotype 3, 20% (n=3/15) and genotype 2, 6% (n=1/15). Among them, 8 out of 15 (53.3%) patients had normal trigliseride (TG) level, 5 out of 15 (33.3%) patients had BMI <25 and 6 out of 15 (40%) patients had high viral load (HVL, >400,000 iu/ml). Conclusions: We observed that the majority of patients with CHC had mild hepatic steatosis, 60% (n=9/15) with normal TG, 53.3% (n=8/15) and amongst genotype 1, 33.3% (n=5/15). Higher viral load might have an influence in the development and progression of steatosis in CHC.

Item Type: Article (Journal)
Additional Information: 3739/12784
Subjects: R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes: Kulliyyah of Medicine > Department of Internal Medicine
Kulliyyah of Medicine > Department of Radiology
Depositing User: Ms Rosyidah Taju Rahim
Date Deposited: 05 Jan 2012 12:12
Last Modified: 05 Jan 2012 12:12
URI: http://irep.iium.edu.my/id/eprint/12784

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