Azhar, Muhammad Daniel Amani and Abdullah, Mohamad Zakkirun and Bakar, Latifah Munirah (2025) Computational docking-based investigation of Garcinia mangostana bioactive compounds as H1N1 influenza A virus neuraminidase. In: Colloquium on Applied Sciences 1 2025, 20 - 24 January 2025, Shah Alam, Malaysia.
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Abstract
The H1N1 influenza virus, responsible for global pandemics, remains a significant public health challenge due to its high transmissibility and frequent mutations that render many antiviral drugs less effective. Current treatments, such as neuraminidase inhibitors, face limitations including drug resistance and adverse side effects. Garcinia mangostana (mangosteen), a tropical fruit traditionally valued for its medicinal properties, contains bioactive compounds with potential antiviral, antioxidant, and anti-inflammatory activities. This study explores the molecular docking of G. mangostana phytochemicals to identify potent inhibitors of the H1N1 neuraminidase enzyme, aiming to provide a foundation for the development of safer, plant-based antiviral therapies.
| Item Type: | Proceeding Paper (Other) |
|---|---|
| Uncontrolled Keywords: | H1N1, Garcinia mangostana, Neuraminidase, Bioactive Compounds, Inhibitor |
| Subjects: | Q Science > QD Chemistry Q Science > QR Microbiology R Medicine > RM Therapeutics. Pharmacology |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences |
| Depositing User: | MOHAMAD ZAKKIRUN ABDULLAH |
| Date Deposited: | 19 Dec 2025 18:00 |
| Last Modified: | 19 Dec 2025 18:00 |
| Queue Number: | 2025-12-Q843 |
| URI: | http://irep.iium.edu.my/id/eprint/125697 |
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