Roslan, Nurul Syafiqah Amirah and Abdullah, Mohamad Zakkirun and Bakar, Latifah Munirah (2025) Computational analysis of Curcuma aeruginosa bioactive compounds for their potential to inhibit H1N1 influenza A virus neuraminidase. In: Colloquium on Applied Sciences 1 2025, 20 - 24 January 2025, Shah Alam, Malaysia.
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Abstract
The H1N1 virus presents a significant public health threat in Malaysia because of its high morbidity and mortality rates. High mutation rates of the virus have increased the drug-resistant strains, causing the existing medication to be ineffective. The influenza H1N1 virus possesses two glycoproteins, hemagglutinin and neuraminidase, which play crucial roles in viral replication, making them key targets for antiviral strategies. Additionally, Curcuma aeruginosa from a Zingiberaceae family is known to be rich in bioactive compounds, making it a suitable candidate. The purpose of this study is to investigate the potential bioactive compounds from C. aeruginosa that are able to act as H1N1 influenza A virus neuraminidase inhibitors using molecular docking.
| Item Type: | Proceeding Paper (Other) |
|---|---|
| Uncontrolled Keywords: | H1N1 influenza A virus, neuraminidase, Curcuma aeruginosa, bioactive compounds, molecular docking |
| Subjects: | Q Science > QD Chemistry Q Science > QR Microbiology R Medicine > RM Therapeutics. Pharmacology |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences |
| Depositing User: | MOHAMAD ZAKKIRUN ABDULLAH |
| Date Deposited: | 19 Dec 2025 17:44 |
| Last Modified: | 19 Dec 2025 17:44 |
| Queue Number: | 2025-12-Q840 |
| URI: | http://irep.iium.edu.my/id/eprint/125696 |
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