Abu Kassim, Madihah and Haydar Ali Tajuddin, Amalina and Ahmad Kasim, Ahmad Zulhazwan (2025) Alpha-lipoic acid (ALA) in diabetes mellitus-induced erectile dysfunction (DMED): preliminary efficacy from an interim analysis. In: Postgraduate Research Conference (POGRAC2025), 21 November 2025, Bangi, Selangor, Malaysia.
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Abstract
Introduction: Erectile dysfunction (ED) is a common complication of type 2 diabetes mellitus (T2DM) related to endothelial dysfunction, neuropathy and oxidative stress. Alpha-lipoic acid (ALA), a potent antioxidant, has been shown to be beneficial in diabetic neuropathy and adjunctive ED therapy, but its role as monotherapy in diabetes mellitus-induced erectile dysfunction (DMED) remains unclear. Methodology: This ongoing, randomised, single-blind, pilot study evaluates oral ALA 600 mg daily in men with T2DM and mild to moderate ED. Thirty-four participants were randomised in a 1:1 ratio to receive either ALA plus vitamins B1, B6 and B12 or vitamins alone. The primary outcome was change in the 5-item version of the International Index of Erectile Function (IIEF-5) score. Secondary outcomes were changes in serum malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP) and testosterone. Analyses were performed at baseline, six weeks and twelve weeks; the results after six weeks are presented in this report. Results: Twenty-eight participants completed the follow-up. The intervention group showed a mean IIEF-5 increase of +2.36, while the control group demonstrated a slight decline, with a significant time–group interaction (p = 0.015). After baseline adjustment, the effect remained significant (p = 0.017). No differences were found between the groups for serum MDA, hs-CRP and testosterone. Four participants withdrew due to mild side effects; no serious adverse events occurred. Conclusion: ALA may improve erectile function in DMED, although no short-term changes in biomarkers were observed. This interim analysis demonstrates the feasibility and early efficacy of ALA monotherapy in DMED.
| Item Type: | Proceeding Paper (Other) |
|---|---|
| Additional Information: | 7714/124722 |
| Uncontrolled Keywords: | Alpha-lipoid acid; diabetes mellitus-induced erectile dysfunction; high-sensitivity C-reactive protein; IIEF-5; malondialdehyde; testosterone |
| Subjects: | R Medicine > RC Internal medicine > RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Medicine Kulliyyah of Medicine > Department of Internal Medicine Sultan Ahmad Shah Medical Centre (SASMEC) |
| Depositing User: | Dr Amalina Haydar Ali Tajuddin |
| Date Deposited: | 08 Dec 2025 09:17 |
| Last Modified: | 08 Dec 2025 11:48 |
| Queue Number: | 2025-12-Q386 |
| URI: | http://irep.iium.edu.my/id/eprint/124722 |
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