A fatal case of adenovirus encephalitis in an adult with end-stage renal disease

Cheong, Xiong Khee and Tan, Juen Kim and Zainulabid, Ummu Afeera and Kori, Najma and Periyasamy, Petrick Ramesh (2025) A fatal case of adenovirus encephalitis in an adult with end-stage renal disease. Cureus, 17 (11). pp. 1-7. ISSN 2168-8184

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Abstract

The spectrum of adenovirus infection can vary from self-limiting mild respiratory illness or gastroenteritis to fatal disseminated disease in immunocompetent hosts. Severe disseminated disease is commonly seen in immunocompromised hosts, including severe pneumonia with acute respiratory distress syndrome, hepatitis, encephalitis, hemorrhagic cystitis, and shock. Meningoencephalitis is a rare manifestation in immunocompetent adults. Early detection of adenovirus infection is necessary as early initiation of appropriate antiviral therapy may prevent life-threatening complications. In this report, we describe a fatal case of adenovirus encephalitis in an adult with end-stage renal disease (ESRD) who presented with a first-onset seizure. The seizure was preceded by a prodromal respiratory illness and septicemic shock, and the diagnosis was confirmed by cerebrospinal fluid (CSF) polymerase chain reaction (PCR) positivity for adenovirus and characteristic electroencephalography (EEG) findings.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Adenovirus; encephalitis; end-stage renal disease; cerebrospinal fluid
Subjects:	R Medicine > RC Internal medicine > RC111 Infectious and Parasitic Diseases
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Internal Medicine Kulliyyah of Medicine
Depositing User:	Asst. Dr. Ummu Afeera Zainulabid
Date Deposited:	25 Nov 2025 15:57
Last Modified:	25 Nov 2025 15:58
Queue Number:	2025-11-Q129
URI:	http://irep.iium.edu.my/id/eprint/124572

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