Healthy gums does it matter? Amlodipine-induced gingival overgrowth (AIGO): a case report

Mohd Zainal, Abdul Zaki Ar Rasyid and Che' Man, Mohamad and Yatim, Yusnita and Abu Hassan, Nur Hafizah Ainaa (2025) Healthy gums does it matter? Amlodipine-induced gingival overgrowth (AIGO): a case report. Asian Journal of Medicine and Health Sciences, 8 (2). pp. 261-266. E-ISSN 2637-0603

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Abstract

In Malaysia, more than half a million adults, representing 2.5% of the population, are living with four major non-communicable diseases (NCDs): diabetes, hypertension, hypercholesterolemia, and obesity. As for hypertension, 29.2% or 1 in 3 adults in Malaysia have hypertension, and 91% are on blood pressure medications. This includes dihydropyridine calcium channel blockers such as amlodipine, which is commonly used in primary care. We report a case from our primary care clinic involving a 70-year-old man with a known history of primary hypertension who developed painless gum swelling and discomfort while the patient was on T. amlodipine 10 mg. Oral examination showed diffuse gingival hypertrophy involving the upper and right lower gums. The condition resolved completely after discontinuation of the offending drug and substitution with an angiotensin-converting enzyme inhibitor. This case is notable because the gingival overgrowth developed only after 4 years of amlodipine 10 mg therapy. This paper aims to bring clinicians' attention to these adverse effects of amlodipine, so that timely and effective management can be given to the patient, avoiding complications and unnecessary treatment

Item Type:	Article (Case Report)
Additional Information:	124541/6884
Uncontrolled Keywords:	Hypertension, Gingival Overgrowth, dihydropyridine calcium channel blocker
Subjects:	R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RK Dentistry R Medicine > RM Therapeutics. Pharmacology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Family Medicine (Effective: 1st January 2011)
Depositing User:	nur hakimah a manan
Date Deposited:	19 Nov 2025 12:21
Last Modified:	19 Nov 2025 12:21
Queue Number:	2025-11-Q103
URI:	http://irep.iium.edu.my/id/eprint/124541

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