Neuroprotective agents: implications for Parkinson's disease treatment

Algantri, Khaled Ramadan and Mohamed, Wael Mohamed Yousef and Mohd Nasir, Mohd Hamzah and Fata Nahas, Abdul Rahman Mahmoud (2025) Neuroprotective agents: implications for Parkinson's disease treatment. Current Alzheimer research, 22 (9). pp. 634-660. ISSN 1567-2050 E-ISSN 1875-5828

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Abstract

Parkinson's disease (PD) is a multifaceted neurodegenerative condition marked by the progressive loss of dopaminergic neurons, leading to impairments in movement and cognition. This research offers an in-depth examination of the pathophysiological pathways associated with PD, emphasising the roles of oxidative stress, mitochondrial dysfunction, and neuroinflammation. The study examines the interaction between genetic and environmental factors in the development of PD, highlighting the significance of oxidative stress, mitochondrial dysfunction, and excitotoxicity in the degeneration of dopaminergic neurons. It also looks into the impact of neuroinflammation and microglial activation on the causes of PD. Despite considerable progress in research, there remains a lack of effective treatments that can modify the course of the disease, highlighting the pressing need for new therapeutic approaches that address mitochondrial malfunction, oxidative stress, and neuroinflammation. This study assesses the neuroprotective efficacy of various substances, notably natural agents like resveratrol, curcumin, ginsenoside, and melatonin, for managing PD. Although these natural chemicals show promise, further robust clinical trials are needed to confirm their effectiveness and safety, as well as to investigate their potential incorporation into conventional PD treatment

Item Type:	Article (Review)
Uncontrolled Keywords:	Neuroprotective agents, Parkinson’s disease (PD), reactive oxygen species (ROS), substantia nigra pars compacta (SNpc), bradykinesia, mitochondrial dysfunction
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmacy Practice Kulliyyah of Science Kulliyyah of Science > Department of Biotechnology Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr Wael Mohamed
Date Deposited:	17 Nov 2025 10:37
Last Modified:	17 Nov 2025 10:37
URI:	http://irep.iium.edu.my/id/eprint/123820

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