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Bioactive constituents from the leaves of Melastoma Malabathricum L

Darnis, Deny Susanti and Mohd. Sirat, Hasnah and Ahmad, Farediah and Mat Ali, Rasadah (2008) Bioactive constituents from the leaves of Melastoma Malabathricum L. Jurnal Ilmiah Farmasi, 5 (1). pp. 1-8.

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Phytochemical and bioactivity studies of the leaves of Melastoma malabathricum L. (Melastomataceae) have been investigated. The n-hexane extract yielded α-amyrin, patriscabatrine and auranamide, ethyl acetate extract gave quercetin and quercitrin, and methanol extract gave quercitrin and kaempferol-3-O-(2”,6”-di-O-p-trans-coumaroyl)glucoside. The crude extracts and isolated compounds were screened for their antioxidant and cytotoxic activities. The antioxidant assay was carried out by FTC and DPPH radical scavenging method. Kaempferol-3-O-(2”,6”-di-Op- trans-coumaroyl)-glucoside, quercetin and quercitrin showed strong activities with inhibition more than 90% in the FTC method. Quercetin was found to be the most active as radical scavenger in DPPH method with IC50 of 0.69 µM. α-Amyrin and kaempferol-3-O-(2”,6”-di-O-p-transcoumaroyl) glucoside demonstrated the strongest activities in the anti-inflammatory assay of TPA mouse ear oedema with IC50 of 0.11 and 0.34 mM/ear, respectively.

Item Type: Article (Journal)
Additional Information: 5641/1227
Uncontrolled Keywords: Antiinflammatory, Antioxidant, Flavonoids, Melastomataceae, Melastoma malabathricum, Terpenoid
Subjects: Q Science > Q Science (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Science
Kulliyyah of Science > Department of Biomedical Science
Depositing User: Ms Zati Atiqah Mohamad Tanuri
Date Deposited: 29 Jul 2011 14:37
Last Modified: 29 Jul 2011 14:37
URI: http://irep.iium.edu.my/id/eprint/1227

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