The antiparasitic potential of flavonols: a systematic review

Mohd Sabri, Ahmad Akmal and Begum, Taslima and Helal Uddin, A.B.M. and Khattak, Muhammad Muzaffar Ali Khan and Azmi, Syed Najmul Hejaz and Iqubal, Sm Shakeel and Zakaria, Zainul Amiruddin and Ahmed, Qamar Uddin (2025) The antiparasitic potential of flavonols: a systematic review. International Journal of Allied Health Sciences, 9 (2). pp. 3232-3255. ISSN 2600-8491

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Abstract

Background: Parasites represent a significant global health burden, especially in tropical and subtropical regions. Despite the availability of different types of antiparasitic drugs, their harmful side effects and limited treatment options highlight the urgent need for new therapeutic alternatives. Additionally, the development of resistance to existing medications complicates treatment efficacy. Consequently, researchers are focusing on compounds found in medicinal plants, particularly flavonols, due to their potential to inhibit parasite growth effectively. This review aims to establish an evidence-based foundation for developing novel flavonol-based antiparasitic drugs that can effectively combat parasites. Method: The review adhered to the methodological rigor outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines.Specific keywords related to flavonols and antiparasitic activity were used in a systematic search of databases, including PubMed, Web of Science, ProQuest, and Science Direct. The methodological quality of the included papers was judged using the QuADS criteria. Results: The systematic review included 44 studies after screening 1,629 papers based on eligibility criteria. The study compiles 43 compounds and several plant extracts containing flavonols, all of which have demonstrated antiparasitic properties. Conclusion: This review summarizes various flavonols with differing levels of potential to combat a wide range of protozoan parasites, along with their mechanisms of action. However, more in-depth and detailed research is still needed to fully explore the potential of flavonols as future safe antiparasitic agents.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Flavonols; flavonols derivatives; parasites; antiparasitic effects
Subjects:	Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences Kulliyyah of Allied Health Sciences > Department of Nutrition Sciences Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr Qamar Uddin Ahmed
Date Deposited:	31 Jul 2025 11:34
Last Modified:	31 Jul 2025 11:34
URI:	http://irep.iium.edu.my/id/eprint/122391

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