When two worlds collide: acute HIV in the shadow of DADA2 deficiency

Zainulabid, Ummu Afeera and Cheong, Xiong Khee and Kori, Najma and Othman, Siti Norlia and Nawawi, Mohammad Ismim Putera and Ali, Adli and Periyasamy, Petrick (2025) When two worlds collide: acute HIV in the shadow of DADA2 deficiency. In: 35th Congress of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID Global), 11th - 15th April 2025, Messe Vien, Austria, Vienna.

Preview	PDF - Supplemental Material Download (87kB) | Preview
	PDF - Published Version Restricted to Registered users only Download (933kB) | Request a copy

Abstract

Deficiency of adenosine deaminase 2 (DADA2) is a rare autoinflammatory and immunodeficiency disorder characterized by systemic inflammation, recurrent fever, vasculopathy, and immunological abnormalities. Its clinical features can overlap with those of acute viral infections, posing significant diagnostic challenges. Acute HIV infection is frequently associated with a febrile viral syndrome, which can mimic the symptoms and disease progression of DADA2. Here, we report a case of acute HIV infection in an adolescent with underlying DADA2, highlighting the diagnostic complexity due to overlapping clinical features.

Item Type:	Proceeding Paper (Poster)
Uncontrolled Keywords:	Deficiency of adenosine deaminase 2; HIV
Subjects:	R Medicine > RC Internal medicine > RC111 Infectious and Parasitic Diseases
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	Asst. Dr. Ummu Afeera Zainulabid
Date Deposited:	27 Oct 2025 12:53
Last Modified:	27 Oct 2025 12:53
URI:	http://irep.iium.edu.my/id/eprint/121932

Actions (login required)

View Item