From fish fin injury to Mycobacteroides abscessus: precision diagnosis in a complex case using shotgun metagenomics

Zainulabid, Ummu Afeera and Cheong, Xiong Khee and Kori, Najma and Abdullah, Shalimar and Chia Hua, Lim and Khalid, Kashfullah and Mohammed Rusli, Emilia Rosniza and Aziz, Muhammad Nazri and Wai-Mun, Leong and Xin Yi, Chew and Abdul Rahman, Ahmad Yamin and Periyasamy, Petrick (2025) From fish fin injury to Mycobacteroides abscessus: precision diagnosis in a complex case using shotgun metagenomics. In: ESCMID Global 2025, 11 - 15 April 2025, Messe Wien, Vienna, Austria.

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Abstract

Mycobacteroides abscessus, a rapidly growing nontuberculous mycobacterium, is known for multidrug resistance and ability to cause chronic infections. Diagnosis can be challenging when standard culture methods fail. Shotgun metagenomic sequencing (mNGS! provides a culture-independent method for identifying pathogens directly from clinical samples. This report details a case of M. abscessus tenosynovitis in a 57-year-old fishmonger following a fish fin injury, where mNGS enabled diagnosis and guided targeted antibiotic therapy after initial cultures and empiric treatments failed.

Item Type:	Proceeding Paper (Poster)
Uncontrolled Keywords:	Mycobacteroides abscessus; shotgun metagenomics
Subjects:	R Medicine > RC Internal medicine > RC111 Infectious and Parasitic Diseases
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	Asst. Dr. Ummu Afeera Zainulabid
Date Deposited:	04 Jul 2025 10:50
Last Modified:	04 Jul 2025 10:51
URI:	http://irep.iium.edu.my/id/eprint/121856

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