A blue-hued mystery: primaquine-induced methemoglobinemia in mixed infection with Plasmodium vivax and Plasmodium falciparum

Zainulabid, Ummu Afeera and Cheong, Xiong Khee and Periyasamy, Petrick and Mohd Salleh, Ahmad Firdaus and Ghazali, Nurraffini and Hassan, Noor Wanie and Sangaran, Kumuthamalar and Mohd Yassin, Azlin and Md Idris, Zulkarnain (2025) A blue-hued mystery: primaquine-induced methemoglobinemia in mixed infection with Plasmodium vivax and Plasmodium falciparum. In: ESCMID Global 2025, 11 - 15 April 2025, Messe Wien, Vienna, Austria.

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Abstract

Primaquine-induced methemoglobinemia is a rare but serious adverse effecect, typically observed in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Although G6PD screening is routinely performed before primaquine administration, methemoglobinemia can still occur in patients with normal G6PD activity. This case highlights the importance of recognizing this rare complication in patients with mixed ma- laria infections, even in the absence of known risk factors, and underscores the role of molecular diagnostics in confirming the infecting species.

Item Type:	Proceeding Paper (Poster)
Uncontrolled Keywords:	Primaquine; malaria; Plasmodium vivax; Plasmodium falciparum
Subjects:	R Medicine > RC Internal medicine > RC111 Infectious and Parasitic Diseases
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	Asst. Dr. Ummu Afeera Zainulabid
Date Deposited:	04 Jul 2025 09:31
Last Modified:	04 Jul 2025 10:14
URI:	http://irep.iium.edu.my/id/eprint/121837

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