Ocular surface changes in patients with type 2 diabetes mellitus: evidence from Palestine

Aljarousha, Mohammed and Osman, Ahmed Mohamed Yehia and Shaqoura, Emad IH and Farajallah, Iman and Azman, Nahdiyah (2025) Ocular surface changes in patients with type 2 diabetes mellitus: evidence from Palestine. Pakistan Journal of Ophthalmology, 41 (3). pp. 248-252. ISSN 0886-3067 E-ISSN 2789-4347

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Abstract

Purpose: To determine the ocular surface disease in patients with Type 2 diabetes mellitus (DM) by using translated and validated Arabic version of Ocular Surface Disease Index (Arab-OSDI) and the clinical measurements. Study Design: Cross-sectional study. Methods: A total of 30 patients with Type 2DM and 30 non-diabetic controls were included in this study. All participants, who were non-contact lens users, completed the Arab-OSDI questionnaire and underwent clinical evaluations including tear break-up time (BUT), meibomian gland assessments, tear meniscus height (TMH), Marx line (ML), Schirmer II tear test, fluorescein corneal staining (F/S), and lissamine green conjunctival staining (LGS) were recruited. Dry eye (DE) was diagnosed when Arab-OSDI scores were ≥13 and BUT was <5 seconds. Results: The DM and non-DM groups demonstrated notable differences in the outcomes of Arab-OSDI (p = 0.017) and the evaluations of meibomian gland (p = 0.022). Within the DM group, individuals with dry eye showed significantly elevated Arab-OSDI results compared to those without dry eye (p = 0.014), whereas the other clinical parameters showed no statistically significant differences. Conclusion: Individuals with Type-2 DM may experience damage to the lacrimal functional unit, leading to tear deficiency or evaporative DE. This altered tear composition may increase DE symptoms, as reflected in elevated Arab-OSDI scores.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Keywords: Ocular surface disease, Diabetes Mellitus, Ocular surface disease index.
Subjects:	R Medicine > RE Ophthalmology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmacy Practice
Depositing User:	Dr. AHMED OSMAN
Date Deposited:	02 Jul 2025 09:15
Last Modified:	02 Jul 2025 09:15
URI:	http://irep.iium.edu.my/id/eprint/121823

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