Genome-wide association study of long COVID

Lammi, Vilma and Nakanishi, Tomoko and Jones, Samuel E. and Andrews, Shea J. and Karjalainen, Juha and Cortés, Beatriz and O’Brien, Heath E. and Ochoa-Guzman, Ana and Fulton-Howard, Brian E. and Broberg, Martin and Zainulabid, Ummu Afeera (2025) Genome-wide association study of long COVID. Nature Genetics, NA (NA). pp. 1-16. ISSN 1061-4036 E-ISSN 1546-1718

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Abstract

Infections can lead to persistent symptoms and diseases such as shingles after varicella zoster or rheumatic fever after streptococcal infections. Similarly, severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection can result in long coronavirus disease (COVID), typically manifesting as fatigue, pulmonary symptoms and cognitive dysfunction. The biological mechanisms behind long COVID remain unclear. We performed a genome-wide association study for long COVID including up to 6,450 long COVID cases and 1,093,995 population controls from 24 studies across 16 countries. We discovered an association of FOXP4 with long COVID, independent of its previously identified association with severe COVID-19. The signal was replicated in 9,500 long COVID cases and 798,835 population controls. Given the transcription factor FOXP4’s role in lung physiology and pathology, our findings highlight the importance of lung function in the pathophysiology of long COVID.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Long COVID; FOXP4; SARS-CoV-2
Subjects:	R Medicine > RC Internal medicine > RC111 Infectious and Parasitic Diseases
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Internal Medicine
Depositing User:	Asst. Dr. Ummu Afeera Zainulabid
Date Deposited:	26 May 2025 11:15
Last Modified:	26 May 2025 11:30
URI:	http://irep.iium.edu.my/id/eprint/121189

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