Mantle cell lymphoma with negative CCND1 FISH studies: a case report

Abdul Halim, Sarah and Mohd Nasiruddin, Dhamirah Nazihah and Nordin, Mohammad Hudzaifah and Adzahar, Sumaiyah (2025) Mantle cell lymphoma with negative CCND1 FISH studies: a case report. Asian Journal of Medicine and Biomedicine, 9 (1). pp. 1-5. E-ISSN 2600-8173

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Abstract

Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterised by the overexpression of cyclin D1 due to a chromosomal translocation of t (11;14) (q13;q32) in most cases. This abnormal cyclin D1 expression is a key factor in diagnosing MCL. Morphologically, MCL typically manifests as a proliferation of small- to medium-sized cells with irregular nuclear contours. In aggressive variants, such as those comprising lymphoblast-like (blastoid) or pleomorphic cells, the disease course may be more rapid and challenging to manage. Notably, a rare cyclin D1-negative variant of MCL has been identified, characterised by translocations involving CCND2/cyclin D2. We present a case of MCL with negative CCND1/IGH rearrangement, contributing to the broader understanding of the disease's varied manifestations.

Item Type:	Article (Case Report)
Uncontrolled Keywords:	Mantle cell lymphoma, non-Hodgkin’s lymphoma, CCND1, FISH studies
Subjects:	R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Pathology & Lab Medicine
Depositing User:	Dr SARAH ABDUL HALIM
Date Deposited:	15 May 2025 09:37
Last Modified:	15 May 2025 09:37
URI:	http://irep.iium.edu.my/id/eprint/120978

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