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Mangostins and their bioactivities from garcinia Malaccensis HK.F

Bakhtiar, M. Taher and Darnis, Deny Susanti and Ahmad Zohri, Farah Syahidah and Arief Ichwan, Solachuddin Jauhari and Rezali, Mohd Fazlin (2010) Mangostins and their bioactivities from garcinia Malaccensis HK.F. Malaysian Journal of Pharmaceutical Sciences, 8 (sup.1). p. 13. ISSN 1675-7319

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Introduction: Guttiferae is a well-known family having a wide range of phytochemical constituents and bioactivities. Objectives: To investigate phytochemicals and bioactivities of Garcinia malaccensis. Materials and Methods: The isolated compounds were elucidated by spectroscopic methods. Antimicrobial activity was carried out by disc diffusion method. Antiproliferative activity was performed by tryphan blue exclusion and MTT assay. Antioxidant activity was conducted by DPPH radical scavenging. Results: Phytochemicals investigation of the stem bark of G. malaccensis lead to isolation of -mangostin, -mangostin and a triterpenoid. The main priority of this study’s activity was done on -mangostin as the compound was found as a major constituent. Results showed that -mangostin inhibits Staphylococcus aureus. The diameter of inhibition zone observed was 8 mm, minimum inhibition concentration (MIC) was 0.025 mg/mL and minimum bactericidal concentration (MBC) was 0.1 mg/mL. Dot-blot DPPH staining showed a positive antioxidant activity of -mangostin. In FTC method, -mangostin was proved to be a good lipid peroxidation inhibitor, whereas in DPPH free radical scavenging activity method, it has a very weak scavenging effects on free radicals. In the antiproliferative assay, -mangostin exhibited activity against K562 (IC50 20 μg/mL) and showed a weak activity against HSC3 and H1299 cell lines.

Item Type: Article (Journal)
Additional Information: 5209/12061
Uncontrolled Keywords: Mangostins, Garcinia Malaccensis
Subjects: R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Technology
Depositing User: Dr Muhammad Taher
Date Deposited: 11 Jan 2012 15:59
Last Modified: 13 Mar 2012 08:20
URI: http://irep.iium.edu.my/id/eprint/12061

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