Unveiling the essential oil composition and bioactivities of Piper frustratum Boerl

Wan Idrus, Syarifah Nadhirah and Wan Salleh, Wan Mohd Nuzul Hakimi and Salihu, Abubakar Siddiq and Arzmi, Mohd Hafiz and L. Cespedes-Acuña, Carlos (2025) Unveiling the essential oil composition and bioactivities of Piper frustratum Boerl. Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 80 (11). pp. 769-774. ISSN 0939-5075 E-ISSN 1865-7125

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Abstract

This study aimed to investigate the chemical composition, and anticholinesterase and anti-tyrosinase activities of the essential oil extracted from the leaves of Piper frustratum Boerl., growing in Malaysia. Nineteen chemical components were identified using gas chromatography-flame ionization detection (GC-FID) and gas chromatography-mass spectrometry(GC-MS),accountingfor99.6 %oftheessentialoil. The identified major components include β-caryophyllene (12.6 %), β-asarone (10.7 %), myristicin (10.4 %), α-copaene (9.6 %), methyl eugenol (7.2 %), and β-cubebene (6.5 %). Anticholinesterase activity was assessed using the Ellman’s method, while anti-tyrosinase activity was evaluated against mushroom tyrosinase. The essential oil demonstrated moderate inhibitory activity against acetylcholinesterase (IC50 value of 84.2 μg/mL), butyrylcholinesterase (IC50 value of 98.5 μg/mL),

Item Type:	Article (Journal)
Uncontrolled Keywords:	piperaceae; essential oil; Piper frustratum; β-caryophyllene; cholinesterase; tyrosinase
Subjects:	Q Science > QR Microbiology R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences
Depositing User:	AP Ts Dr Mohd Hafiz Arzmi
Date Deposited:	16 Dec 2025 18:44
Last Modified:	19 Dec 2025 11:44
Queue Number:	2025-12-Q1005
URI:	http://irep.iium.edu.my/id/eprint/120469

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