An unusual case of multiple primary tumours involving the long bone and oral cavity

Sekar, Karthick and Ramanathan, Anand and Khalid, Rafiq and Kein, Seong Mun and Valliappan, Valliammai and Ismail, Siti Mazlipah (2025) An unusual case of multiple primary tumours involving the long bone and oral cavity. Oral and Maxillofacial Surgery, 29 (62). pp. 1-5. ISSN 1865-1550 E-ISSN 1865-1569

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Abstract

Purpose of Review Multiple primary tumours (MPTs) are a rare clinical entity, and the co-occurrence of synchronous and metachronous MPTs in a single patient is even more exceptional. In the context of Erdheim-Chester Disease (ECD), an already uncommon disorder, the presentation of this disease in the oral cavity is notably rare. Furthermore, the simultane- ous presence of ECD in the oral cavity and a Giant Cell Tumour (GCT) in a long bone has not been previously reported in medical literature. Recent findings This case report presents the first documented instance of such a unique clinical scenario. The marked his- tological disparities between GCT and ECD further underscore the enigmatic nature of this case. The intricate interplay of genetic, environmental, and pathophysiological factors that led to the simultaneous development of two distinct neoplasms in the same patient is yet to be fully elucidated. Summary This case not only challenges our understanding of the etiology of these conditions but also emphasizes the importance of a multidisciplinary approach to the evaluation and management of such complex cases. The confluence of rare entities, the diagnostic complexities they introduce, and the imperative need for tailored treatment strategies exemplify the intricate landscape of oncological care. This case serves as a compelling reminder of the many unknown facets of dis- ease etiology and the significance of collaborative medical efforts in offering the best possible care for patients confronting exceptionally rare clinical presentations.

Item Type:	Article (Case Report)
Uncontrolled Keywords:	Multiple primary tumours · Erdheim-Chester Disease · Giant cell tumour · Synchronous tumours · Unusual clinical presentation
Subjects:	R Medicine > R Medicine (General) R Medicine > RK Dentistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Oral Maxillofacial Surgery and Oral Diagnosis
Depositing User:	Dr Rafiq Khalid
Date Deposited:	17 Mar 2025 14:49
Last Modified:	21 Mar 2025 11:55
URI:	http://irep.iium.edu.my/id/eprint/120275

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