Zulhazman, Nurantasha and Azidi, Mohamad Afiq and Muhd Helmi, Muhd Alwi and Haris @ Harith, Muhammad Salahuddin and Harith, Sakinah and Mohd Rus, Shaiqah (2025) The growth-promoting effect of omega-3 on children: a systematic literature review. Malaysian Journal of Medicine and Health Sciences, 21 (1). pp. 282-292. ISSN 1675-8544 E-ISSN 2636-9346
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Abstract
Introduction: Poor growth and development can have long-term adverse health impacts, including increased birth defects, impaired cognitive function, and low academic achievement. Essential nutrients, such as omega-3 fatty acids, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), offer various health benefits. However, the impact of omega-3 on children's growth is under-researched, with studies typically focusing on single domains like cognitive development. This study aims to review the growth-promoting benefits of omega-3 on children across multiple growth domains. Materials and methods: Following PRISMA guidelines and registered with PROSPERO (CRD42023417580), three databases—PubMed, Scopus, and Cochrane Library—were searched for relevant articles from 2018 to 2022. The Cochrane Risk of Bias Tool for randomized trials (RoB2) was used to assess bias risk, and Mendeley was used to manage and deduplicate articles. Results: Seven randomized clinical trials (RCTs) from 2018 to 2020 were reviewed. Only one study found a significant positive impact of omega-3 on children's cognitive development, while five studies did not. One study explored neurodevelopment, and two RCTs from the UK and Spain examined behavioral outcomes. A study from Indonesia assessed physical growth. Conclusion: Overall, omega-3 fatty acids did not show a significant impact on early childhood development. Omega-3 supplements may enhance behavioral development and physical growth in children but do not significantly affect cognitive or neurodevelopment.
| Item Type: | Article (Review) |
|---|---|
| Uncontrolled Keywords: | Growth-promoting effects, Omega-3, EPA, DHA, Children |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Medicine Kulliyyah of Medicine > Department of Paediatrics |
| Depositing User: | Dr. Muhammad Salahuddin Haris |
| Date Deposited: | 17 Feb 2025 14:39 |
| Last Modified: | 17 Feb 2025 14:39 |
| URI: | http://irep.iium.edu.my/id/eprint/119739 |
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