Occurrence analysis of alpha-mangostin from different organs of Garcinia mangostana L.

Ahmad Izuren Shah, Nurin Syamimi and Abu Bakar, Mohd Rushdi and Taher, Muhammad and Danial, Wan Hazman and Adam, Fatmawati and Abd Rahim, Syarifah (2025) Occurrence analysis of alpha-mangostin from different organs of Garcinia mangostana L. Natural Product Research. pp. 1-5. ISSN 1478-6419 E-ISSN 1478-6427

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Abstract

Alpha-mangostin (AM) is a naturally occurring xanthone with remarkable pharmacological properties, including anti-inflammatory, anti-bacterial, and antioxidant effects. The compound is commonly extracted from the pericarps of Garcinia mangostana L. fruits, but its seasonal availability is limited. Investigating the potential of using various organs of the tree for AM extraction can help mitigate limitations imposed by the seasonal availability of fruits. This study employs the Soxhlet extraction method and gravitational column chromatography for the preparation of AM from various plant organs. The purity of the compound in the extract was quantitatively determined using high-performance liquid chromatography analysis. The stem barks demonstrated the highest yield at 1.3%, with a concentration of 324.593 μg/mL and a purity of 95.215% for AM. The finding is expected to assist in uncovering alternative sources of AM and contribute to sustainable utilisation of the tree, as various plant organs could be employed in AM extraction.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Xanthone; Garcinia mangostana L; Soxhlet extraction; purity; yield
Subjects:	Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology T Technology > TP Chemical technology T Technology > TP Chemical technology > TP155 Chemical engineering
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Pharmaceutical Technology Kulliyyah of Science > Department of Chemistry Kulliyyah of Pharmacy Kulliyyah of Science
Depositing User:	Dr Mohd Rushdi Abu Bakar
Date Deposited:	10 Jan 2025 13:39
Last Modified:	10 Jan 2025 13:39
URI:	http://irep.iium.edu.my/id/eprint/118534

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