Impact of the SAC:CBZ ratio on polymorphic transformation and morphology of carbamazepine-saccharin co-crystals using fast cooling crystallization

Mohammad, Khairool Azizul and Wei, Michelle H. S. and Zainudin, Engku Nur Aisha Huda and Abd Rahim, Syarifah (2024) Impact of the SAC:CBZ ratio on polymorphic transformation and morphology of carbamazepine-saccharin co-crystals using fast cooling crystallization. Journal of Thermal Analysis and Calorimetry (JTAC), 149. pp. 10901-10913. ISSN 1388-6150 E-ISSN 1588-2926

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Abstract

Carbamazepine-saccharin (CBZ-SAC) co-crystal is one of the most studied co-crystals to date. It is proven to be polymorphic, consisting of Form I (plate-like shape) and Form II (needle-like shape), which is rarely reported by researchers. The present study aimed to study the effect of SAC:CBZ ratio on the polymorphic transformation and morphology of CBZ-SAC cocrystals using ice bath fast cooling crystallization. A series of CBZ-SAC co-crystals were produced from different SAC:CBZ mol ratios (1:1, 2:1, 3:1, 4:1, 5:1, 6:1) and were compared in terms of their crystal form and morphology under microscope. The polymorphic changes were also studied from the CBZ-SAC suspension during co-crystallization process. The polymorphs of CBZ-SAC co-crystals were identified using PXRD, DSC, ATR-FTIR. The results showed that at lower ratio (1:1, 2:1, 3:1), only plate-like shaped crystals (Form I) was present. For higher mol ratio (4:1, 5:1, 6:1), mixture of Form I and II of CBZ-SAC co-crystals were observed and further confirmed by DSC and ATR-FTIR. The nucleation process showed that Form II could convert to Form I when varying the SAC:CBZ ratio. Hence, it is proven that SAC:CBZ mol ratio can affect the polymorphic transformation and morphology of CBZ-SAC co-crystals. Nonetheless, other parameters should be used to further study the formation of CBZ-SAC co-crystals since pure CBZ-SAC Form II co-crystals were not obtained in this study.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Carbamazepine, Saccharin, Co-crystals, Polymorphic, Morphology, Fast cooling
Subjects:	R Medicine > RS Pharmacy and materia medica
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Basic Medical Sciences Kulliyyah of Pharmacy
Depositing User:	Dr Engku Nuraishah Huda E.Zainudin
Date Deposited:	10 Jan 2025 15:13
Last Modified:	10 Jan 2025 15:13
URI:	http://irep.iium.edu.my/id/eprint/117633

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