Abd Rahim, Nour El Huda and Mohamad Amri, Nur Fathonah and Zulkifly, Ahmad Hafiz and Hassan, Habibah and Mohd Jan, Nurul Hafiza and Ibrahim, Mohd Zulfadzli (2024) Exploring Tualang Honey formulation and Synvisc in rabbit osteoarthritis. Malaysian Orthopaedic Journal, 17 (Suppl. A). p. 1. ISSN 1985-2533 E-ISSN 2232-111X
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Abstract
INTRODUCTION: Tualang Honey, characterised by its anti-inflammatory and antioxidative properties, presents a novel therapeutic approach to osteoarthritis (OA) management. This study evaluates the efficacy of a Tualang Honey Formulation (THF) (Patent no. MY179303-A) injection, compared to Synvisc, a conventional hyaluronic acid injection, utilising radiographic findings in New Zealand White Rabbits (NZWR) as an OA model. MATERIALS & METHODS: A controlled experiment was conducted on 24 OA-induced NZWR. Two experimental groups received THF and Synvisc intraarticularly after 3 weeks post-surgery. The rabbits were then euthanised, and x-rays were taken at 3, 6, 12, and 24 weeks to evaluate joint space narrowing and subchondral sclerosis as indicators of OA progression. RESULTS: At 3 and 6 weeks, both groups demonstrated an improving condition in radiographic signs of OA, with no significant difference between them. At 12 weeks, the THF group showed a trend towards better preservation of joint space. By 24 weeks, the radiographic outcomes of THF were comparable to the Synvisc group, with no significant differences of OA progression. DISCUSSIONS: The findings suggest that THF may offer a comparable alternative to Synvisc injections in managing OA, with the potential benefits of natural and halal composition and lower cost. However, further studies are needed to assess the long-term clinical outcomes and potential systemic effects of THF. CONCLUSION: THF injection is as effective as Synvisc hyaluronic acid injection in reducing radiographic signs of OA in New Zealand White Rabbits at 24 weeks, making it a potential candidate as a viscosupplement in the non-surgical management of OA.
| Item Type: | Article (Abstract) |
|---|---|
| Additional Information: | 6300/116541 |
| Uncontrolled Keywords: | Tualang Honey, Synvis, Osteoarthritis, New Zealand White Rabbits |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RD Surgery R Medicine > RD Surgery > RD701 Orthopedics |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation |
| Depositing User: | Dr Nour El Huda Abd Rahim |
| Date Deposited: | 10 Dec 2024 14:58 |
| Last Modified: | 10 Dec 2024 15:09 |
| URI: | http://irep.iium.edu.my/id/eprint/116541 |
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