Atypical antipsychotic lumateperone beyond schizophrenia: seeking clarity in a time of uncertainty

Mohamed, Wael Mohamed Yousef (2025) Atypical antipsychotic lumateperone beyond schizophrenia: seeking clarity in a time of uncertainty. In: Essential Guide to Neurodegenerative Disorders Mechanistic, Diagnostic and Therapeutic Advances. Elsevier, London, UK, pp. 461-467. ISBN 9780443157028

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Abstract

Lumateperone (ITI-007) is a serotonin 5HT2A tosylate salt with a high affinity for dopamine D2 and D1 receptors and the serotonin transporter. It is unusual in that it controls serotonin, dopamine, and glutamate neurotransmission concurrently, all of which have been implicated in severe mental illness. Consider it a multitargeted ligand and multifunctional modulator of the serotoninergic system with possible precognitive, antipsychotic, antidepressant, and anxiolytic properties. While lumateperone has been explored as a new agent for schizophrenia therapy, it also provides a unique therapeutic option for a range of other psychiatric and neurological diseases, including behavioral signs of dementia or Alzheimer's disease, sleep problems, and bipolar depression. Additionally, it had a better safety profile than placebo, with no significant extrapyramidal side effects, hyperprolactinemia, or changes in cardiometabolic or endocrine characteristics. Additional study is needed to validate and analyze lumateperone's effectiveness, as well as to identify prospective therapeutic targets. This article gives a comprehensive overview of the most notable results and potential future applications of this chemical in personalized medicine, particularly for neurodegenerative diseases.

Item Type:	Book Chapter
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr Wael Mohamed
Date Deposited:	05 Dec 2024 15:51
Last Modified:	05 Dec 2024 15:51
URI:	http://irep.iium.edu.my/id/eprint/116442

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