Comparison of oven dried and freeze dried orally disintegrating film (ODF) formulations containing memantine hydrochloride

Phang, Hiu Ching and Tan, Julia M and Subramaniam, Poonguzhali and Helal Uddin, A.B.M. and Ee, Mei Hooi and Lakshminarayanan, Vijayakumar and Liew, Kai Bin (2024) Comparison of oven dried and freeze dried orally disintegrating film (ODF) formulations containing memantine hydrochloride. International Journal of Pharmaceutical Compounding, 28 (5). pp. 423-431. ISSN 1092-4221

	PDF - Published Version Restricted to Repository staff only Download (887kB) | Request a copy
	PDF (SCOPUS) - Supplemental Material Restricted to Registered users only Download (116kB) | Request a copy

Abstract

Non-compliance is a serious healthcare issue. It contributes to waste of medication, deterioration of patient’s quality of life and increase in healthcare cost. It is challenging to ensure Alzheimer's disease patients to comply to their medication daily. Hence, patient friendly and innovative dosage form is required to overcome the challenges. Orally disintegrating film (ODF) is proposed as solution to non-compliance. The objective of this research was to compare oven drying and freeze drying process on the physical properties of memantine hydrochloride ODF. A central composite design was used. The factors considered were concentration of Guar Gum (0.5–1.84g), concentration of wheat starch (0.5–1.84g) and concentration of PEG 400 (0.5–1.84g). A total of 20 formulations for each drying method were prepared. The ODFs produced were then characterized using uniformity of thickness tensile strength, folding endurance, disintegration time test. The optimum formulation was selected and incorporated with memantine hydrochloride. A flexible Memantine hydrochloride ODF formulation with fast disintegration time, sufficient mechanical strength and stable over a period of six months was successfully developed. The optimum formulation has 1.50 g guar gum, 1.50 g starch and 1.50 g of PEG 400. Freeze dried films are preferred as these films are more flexible and porous that lead to faster disintegration time. The findings suggest that memantine hydrochloride ODF has the potential as an alternative dosage form in treating Alzheimer’s disease.

Item Type:	Article (Journal)
Subjects:	Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	Dr. A. B. M. Helal Uddin
Date Deposited:	05 Dec 2024 11:55
Last Modified:	05 Dec 2024 11:55
URI:	http://irep.iium.edu.my/id/eprint/116369

Actions (login required)

View Item