Isoniazid in children – any rationale for post isoniazid liver function test

Abdullah, Ahmad Fadzil and Rusli, Nur Shafinaz (2022) Isoniazid in children – any rationale for post isoniazid liver function test. Malaysian Journal of Paediatrics and Child Health (MJPCH), 28 (1). pp. 29-31. ISSN 1511-4511

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Abstract

Isoniazid (INH) therapy remains the treatment of choice in latent tuberculosis infection (LTBI). However, drug-induced liver injury (DILI) is a known adverse effect of isoniazid. Serum transaminase elevation occurs in about 10% of children receiving INH monotherapy. Drug-induced liver injury can range from asymptomatic increase of aminotransferase to severe liver injury, or in some cases hepatic failure. Even though INH-induced liver injury has been known and extensively studied, its underlying mechanisms are still not fully understood. The liver injury comprises hepatotoxicity and a rarer form of hepatitis hypersensitive allergic reaction. Since the facility to do liver function (LFT) is widely available, monitoring liver function while on INH therapy is the wisest way of monitoring acute liver injury (ATLI).

Item Type:	Article (Journal)
Uncontrolled Keywords:	Isoniazid, Anti-TB drug-induced liver injury (ATLI), latent Tuberculosis infection (LTBI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RJ Pediatrics
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Paediatrics Sultan Ahmad Shah Medical Centre (SASMEC)
Depositing User:	Assc. Prof Ahmad Fadzil
Date Deposited:	26 Nov 2024 07:53
Last Modified:	26 Nov 2024 07:53
URI:	http://irep.iium.edu.my/id/eprint/116079

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