Respiratory support in patients with severe COVID‑19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID‑19 study: a prospective, multinational, observational study

Reyes, Luis Felipe and Murthy, Srinivas and Garcia-Gallo, Esteban and Merson, Laura and Ibáñez-Prada, Elsa D. and Rello, Jordi and Fuentes, Yuli V. and Martin-Loeches, Ignacio and Bozza, Fernando and Duque, Sara and Taccone, Fabio S. and Fowler, Robert A. and Kartsonaki, Christiana and Gonçalves, Bronner P. and Citarella, Barbara Wanjiru and Aryal, Diptesh and Burhan, Erlina and Cummings, Matthew J. and Delmas, Christelle and Diaz, Rodrigo and Figueiredo-Mello, Claudia and Hashmi, Madiha and Panda, Prasan Kumar and Jiménez, Miguel Pedrera and Mat Nor, Mohd Basri (2022) Respiratory support in patients with severe COVID‑19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID‑19 study: a prospective, multinational, observational study. Critical care, 26 (1). ISSN 13648535

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Abstract

Background Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14–1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25–1.30]). Conclusions In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Invasive mechanical ventilation, High flow nasal cannula, COVID-19, Critical care
Subjects:	R Medicine > RC Internal medicine > RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Anaesthesiology & Intensive Care Kulliyyah of Medicine
Depositing User:	Dr. Mohd Basri Mat Nor
Date Deposited:	01 Nov 2024 11:58
Last Modified:	01 Nov 2024 11:58
URI:	http://irep.iium.edu.my/id/eprint/115439

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