The effects of Eurycoma longifolia jack root extract on histological parameters of wound healing

Al-bayati, Maryam Riyadh Yaseen and Faisal, Ghasak Ghazi and Abd. Fuaat, Azliana and Ahmad Affandi, Khairunisa (2024) The effects of Eurycoma longifolia jack root extract on histological parameters of wound healing. Asian journal of Medicine and Biomedicine, 8 (2). pp. 186-196. E-ISSN 2600-8173

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Abstract

Wound healing involves multiple phases and biological events which are tightly regulated. Eurycoma longifolia Jack has potent activity several potent biological activities that can help in healing of wounds. This study aimed to assess the histological changes of wound healing induced by the topical application of Eurycoma longifolia jack extract hydrogel on wounds. A total of 20 Sprague Dawley rats were grouped into 4 groups, negative control untreated, Hydrocyn® aqua gel, vehicle hydrogel (xanthan), and Eurycoma longifolia Jack (TA) hydrogel. Excisional wound was created in all animals. The gel was applied two time a day starting from wounding day. Granulation tissue samples were collected on day 5 post-wounding and histological sections were stained by H&E for histological observation of the quantity inflammatory cells, fibroblasts, degree of new blood vessel formation, re-epithelialization, and collagen density. TA hydrogel group showed a significantly higher number of fibroblasts and collagen fibre density with P-value ≤ 0.05. It also improved angiogenesis and epithelialization and maintained inflammatory cells at a moderate level. Conclusion: TA hydrogel improved all histological parameters of wound healing.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Angiogenesis, Re-Epithelialization, Fibroblasts, Inflammatory Cells.
Subjects:	R Medicine > RB Pathology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences Kulliyyah of Medicine > Department of Pathology & Lab Medicine Kulliyyah of Medicine
Depositing User:	Assoc.Prof Ghasak Ghazi Al-Atrakchi
Date Deposited:	30 Oct 2024 10:26
Last Modified:	30 Oct 2024 10:26
URI:	http://irep.iium.edu.my/id/eprint/115413

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