Muhd Helmi, Muhd Alwi and A Talib, Norlelawati and Abdul Halim, Sarah and Omar, Ahmad Marzuki and Abdullah, Nor Zamzila (2024) Prevalence and hematological impact of Southeast Asian Ovalocytosis in the Malay population: a comparative study. Medicine & Health, 19 (Suppl. 5). p. 4. ISSN 1823-2140 E-ISSN 2289-5728
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Abstract
Introduction: Southeast Asian Ovalocytosis (SeAO) is a hereditary erythrocyte membrane disorder predominantly found in Southeast Asia. It is an autosomal dominant condition and can cause severe haemolysis during the neonatal period. This study aimed to determine the prevalence of SeAO among Malays in Malaysia and compare red blood cell (RBC) parameters between individuals with isolated SeAO and normal individuals. Materials and method: From October 2022 to October 2023, we screened 526 healthy, non-smoking Malays aged 18 to 40 for SeAO and other common hematological conditions affecting RBC parameters, such as thalassemia and anemia. Full blood picture (FBP) and hemoglobin analysis were performed to rule out thalassemia and anaemia. SeAO was diagnosed based on the presence of stomatocytes, macro-ovalocytes, and ≥25% ovalocytes in the FBP. Results: 21 (4.0%) individuals with isolated SeAO (case) and 371 (70.5%) healthy controls (control) were identified from the screening. Significant differences were found in hematocrit level, RBC count, mean corpuscular hemoglobin (MCH), red cell distribution width (RDW), white blood cell (WBC) count, platelet count, and nucleated RBC (NRBC) count (p<0.05) between the case and control groups. Conclusion: This study identified several blood parameters that could potentially be used to screen for SeAO among the Malay population, thereby reducing the time and cost of diagnosis.
| Item Type: | Article (Meeting Abstract) |
|---|---|
| Additional Information: | 7715/115410 |
| Uncontrolled Keywords: | Southeast Asian Ovalocytosis; Malay; blood parameters |
| Subjects: | R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC633 Specialties of Internal Medicines- Diseases of The Blood and Blood-forming Organs. Hematologic Diseases |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Medicine Kulliyyah of Medicine > Department of Family Medicine (Effective: 1st January 2011) Kulliyyah of Medicine > Department of Paediatrics Kulliyyah of Medicine > Department of Pathology & Lab Medicine |
| Depositing User: | Dr Muhd Alwi Muhd Helmi |
| Date Deposited: | 30 Oct 2024 11:20 |
| Last Modified: | 01 Nov 2024 15:20 |
| URI: | http://irep.iium.edu.my/id/eprint/115410 |
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