Genetic studies of apolipoprotein in schizophrenia – a significant systematic review

Wan Mohd Zani, Wan Noorainna Fatimi and Abd Rahim, Nour El Huda and Abdull Jalil, Mohd Asyraf and A Talib, Norlelawati and Azman, Norainin Sofiya and Mat Rasid, Siti Norain and Wan Salleh, Wan Muhamad Salahudin and Kaderi, Mohd Arifin and Md Rosli, Ahmad Nabil (2024) Genetic studies of apolipoprotein in schizophrenia – a significant systematic review. Medicine & Health, 19 (Suppl. 5). p. 65. ISSN 1823-2140 E-ISSN 2289-5728

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Abstract

Introduction: Schizophrenia is a complex multifactorial mental disorder due to genetic, environmental and neurodevelopment. Apolipoprotein is identified as one of various genetic candidates involved in lipid metabolism, neurodevelopment, and neuroprotection. The aim of this systematic review is to combine existing genetic studies on apolipoprotein associated with schizophrenia to understand the potential role in the disorder’s pathogenesis and the implication on lipid metabolism in individuals with schizophrenia. Method: Using the PubMed and Scopus databases, a comprehensive literature review was conducted to search for studies published from 2004 to 2023 restricted to English language. Keywords including “schizophrenia”, “apolipoprotein”, “genetic” and “genetics” were used. Nonresearch materials such as books, reviews, letters to editors, and conference proceedings were excluded during the selection process. Only journal articles that undergo peer review were chosen to increase the reliability and credibility of the systematic review. Results: A total of 45 articles were included in the review and 4 major themes were identified. The themes discussed various topics including genetic polymorphisms, oxidative stress and DNA damage, cognitive functions, lipid metabolism and epigenetic mechanisms associated with schizophrenia. The important roles of apolipoprotein genes such as APOE, APOL and APOA1 were discussed in different aspects of schizophrenia. The APOE gene is the most frequently studied, reflecting the interest in this area of study. Conclusion: This systematic review highlighted several areas on the genetics of apolipoprotein in schizophrenia that could be a basis for future research to focus on identifying specific potential genetic biomarkers to develop better therapeutic interventions.

Item Type:	Article (Meeting Abstract)
Additional Information:	6300/115038
Uncontrolled Keywords:	Genetic; apolipoprotein; biomarkers; schizophrenia; systematic literature review
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RA Public aspects of medicine > RA790 Mental Health. Mental Illness Prevention
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Pathology & Lab Medicine Kulliyyah of Allied Health Sciences Kulliyyah of Allied Health Sciences > Department of Biomedical Science (Effective:1st July 2011) Kulliyyah of Medicine Kulliyyah of Medicine > Department of Psychiatry
Depositing User:	Dr Nour El Huda Abd Rahim
Date Deposited:	11 Oct 2024 15:19
Last Modified:	16 Oct 2024 15:08
URI:	http://irep.iium.edu.my/id/eprint/115038

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