Abu Hanifah, Nabihah and Buyong, Zunariah and Abdullah, Nor Zamzila and Ahmad Affandi, Khairunisa and Abdul Rahim, Roslina and Ahmad, Hajar Fauzan and Kuttulebbai Naina Mohamed Salam, Sirajudeen (2024) The impact of tualang honey on liver weight, adipose tissue, and obesity index in high cholesterol diet-induced obese rats. International Journal of Allied Health Sciences, 8 (Suppl. 3). p. 90. E-ISSN 2600-8491
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Abstract
PURPOSE: This research aimed to investigate the effect of Tualang honey (TH) supplementation on the liver and adipose tissue weight and to evaluate the Lee Obesity Index (LOI) in 12% high cholesterol diet (HCD) induced obese rats. METHODS: Forty male Sprague-Dawley rats were assigned to 5 groups; Group 1 (normal diet), Group 2 (normal diet and TH 3.0g/kg), Group 3 (12% HCD), Group 4 (12% HCD and TH 3.0 g/kg) and Group 5 (12% HCD and Orlistat 10 mg/kg). They were given their diet for 12 weeks followed by treatment for 6 weeks. Their body weight and length were measured once weekly. At the end of the study, the liver and adipose tissue were harvested and weighed. RESULTS: There was a significantly lower liver weight of Group 4 compared to Group 3 (19.05±1.34 g vs 27.41±1.71 g, p<0.001). In normal diet groups, Group 2, have significantly lower liver weight compared to Group 1 (15.46±1.50 g vs 20.53±1.08 g, p<0.001). Supplementation of TH also significantly reduced the accumulation of adipose tissue in Group 4 compared to Group 3 (11.09±1.74 g vs 19.82±2.22 g, p<0.001). LOI in Group 4 is significantly lower compared to Group 3 (302.75±8.21 vs 335.25±11.27, p<0.001) and there is no significant difference in LOI between Group 4 with Group 5 (302.75±8.21 vs 308.38±7.37, p>0.05). CONCLUSION: TH supplementation has been shown to reduce the liver and adipose tissue weight and improve the LOI in the 12% HCD-induced obese rats.
| Item Type: | Article (Abstract) |
|---|---|
| Additional Information: | 9547/114922 |
| Uncontrolled Keywords: | Obesity, Tualang honey, High cholesterol diet, Lee’s Obesity Index, Liver and adipose tissue |
| Subjects: | R Medicine > R Medicine (General) |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine Kulliyyah of Medicine > Department of Pathology & Lab Medicine |
| Depositing User: | Prof.Dr. SIRAJUDEEN KUTTULEBBAI NAINAMOHAMED SALAM |
| Date Deposited: | 11 Oct 2024 09:37 |
| Last Modified: | 11 Oct 2024 10:04 |
| URI: | http://irep.iium.edu.my/id/eprint/114922 |
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