Izhar, Nur Amira and Sainal, Mohd Yusof and Mohamad Salmi, Muhammad Irfan and Elagili, Faisal and Md Nor, Azmi (2024) Microsatellite instability-high in stage IV colorectal cancer: prevalence, and clinicopathological characteristics in Malaysia. Colorectal Disease, 26 (Suppl. 2). p. 51. ISSN 1462-8910 E-ISSN 1463-1318
|
PDF (Abstract)
- Published Version
Download (716kB) | Preview |
Abstract
Aim: The purpose of this study was to estimate the prevalence of Microsatellite Instability High (MSI-H) in stage IV colorectal cancer in Malaysians and to describe MSI-H clinicopathological characteristics. Method: All patients with stage IV colorectal cancer who underwent surgical resection of the primary tumor between January 2017 and December 2020 were included in the single-center retrospective study. MSI status was determined. Clinicopathological features were evaluated. Results: Among 42 patients with stage IV colorectal cancer, 4 patients (10%) had MSI-H (57% were men) with an average age of 58 ± 21 years and were related to left-sided colonic origin, adenocarcinoma, moderately differentiated, lymphovascular invasion, single-organ metastasis, peritoneal metastasis, and Malay race. The average survival durations for MSI-H and Microsatellite Stable (MSS) were 15 ± 14 and 18 ± 16 months, respectively (p= 0.77). Conclusion: In this study, MSI-H was detected in 10% of individuals with stage IV colorectal cancer. However, our data highlight the features and prognostic relevance of MSI-H in Malaysian stage IV colorectal cancer patients.
| Item Type: | Article (Abstract) |
|---|---|
| Additional Information: | 6622/114821 |
| Subjects: | R Medicine > RD Surgery > RD93 Emergency Surgery. Wounds and Injuries |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Medicine > Department of Surgery Kulliyyah of Architecture and Environmental Design > Department of Quantity Surveying Kulliyyah of Medicine |
| Depositing User: | Asst Prof Faisal Elagili |
| Date Deposited: | 03 Oct 2024 10:44 |
| Last Modified: | 03 Oct 2024 15:37 |
| URI: | http://irep.iium.edu.my/id/eprint/114821 |
Actions (login required)
 |
View Item |
Download Statistics
Download Statistics