Mendelian randomization and Parkinson’s disease

Sanyaolu, Arinola O and Mohamed, Wael Mohamed Yousef and Makarious, Mary B and August, Joanne L and Kekenadze, Mariam and Heilbron, Karl and Perinan, Maria T and Noyce, Alastair and Bandres-Ciga, Sara (2024) Mendelian randomization and Parkinson’s disease. In: Integrative Omics in Parkinson’s Disease. Academic Press, Elsevier, London, United Kingdom, pp. 49-74. ISBN 978-0-443-13550-7

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Abstract

This chapter summarizes research related to Mendelian randomization (MR), a robust statistical technique employed to deduce causal links between exposures and outcomes in observational studies. First, we explore MR methods and their uses, clarifying their significance in epidemiological research. We then cover issues related to the execution of MR and provide valuable perspectives on how to effectively manage the intricacies of this approach. Finally, we examine the influence of various exposures on the likelihood of developing Parkinson’s disease (PD), utilizing MR to reveal probable causal connections. We hope this chapter enhances readers’ overall comprehension of MR and its adaptability, limitations, and utility in elucidating causal connections in intricate biological systems. The future development and application of MR have significant potential to enhance our knowledge of risk factors for PD and inform evidence-based interventions.

Item Type:	Book Chapter
Additional Information:	7497/114545
Uncontrolled Keywords:	Assumptions; Exposure; Instrument variable; Mendelian randomization; Multiomics; Omics; Outcome; Parkinson’s disease; Quantitative trait loci; Summary-based data
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical
Depositing User:	Dr Wael Mohamed
Date Deposited:	23 Sep 2024 15:06
Last Modified:	26 Nov 2024 11:29
URI:	http://irep.iium.edu.my/id/eprint/114545

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