Emotion brain network topology in healthy subjects following passive listening to different auditory stimuli

Mohd Rashid, Muhammad Hakimi and Ab Rani, Nur Syairah and Kannan, Mohammed and Abdullah, Mohd Waqiyuddin and Ab Ghani, Muhammad Amiri and Kamel, Nidal and Mustapha, Muzaimi (2024) Emotion brain network topology in healthy subjects following passive listening to different auditory stimuli. PeerJ, 12 (7). pp. 1-34. ISSN 2167-8359

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Abstract

A large body of research establishes the efficacy of musical intervention in many aspects of physical, cognitive, communication, social, and emotional rehabilitation. However, the underlying neural mechanisms for musical therapy remain elusive. This study aimed to investigate the potential neural correlates of musical therapy, focusing on the changes in the topology of emotion brain network. To this end, a Bayesian statistical approach and a cross-over experimental design were employed together with two resting-state magnetoencephalography (MEG) as controls. MEG recordings of 30 healthy subjects were acquired while listening to five auditory stimuli in random order. Two resting-state MEG recordings of each subject were obtained, one prior to the first stimulus (pre) and one after the final stimulus (post). Time series at the level of brain regions were estimated using depth-weighted minimum norm estimation (wMNE) source reconstruction method and the functional connectivity between these regions were computed. The resultant connectivity matrices were used to derive two topological network measures: transitivity and global efficiency which are important in gauging the functional segregation and integration of brain network respectively. The differences in these measures between pre- and post-stimuli resting MEG were set as the equivalence regions. We found that the network measures under all auditory stimuli were equivalent to the resting state network measures in all frequency bands, indicating that the topology of the functional brain network associated with emotional regulation in healthy subjects remains unchanged following these auditory stimuli. This suggests that changes in the emotion network topology may not be the underlying neural mechanism of musical therapy. Nonetheless, further studies are required to explore the neural mechanisms of musical interventions especially in the populations with neuropsychiatric disorders.

Item Type:	Article (Note)
Subjects:	R Medicine > RA Public aspects of medicine > RA790 Mental Health. Mental Illness Prevention R Medicine > RC Internal medicine > RC321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RZ Other systems of medicine > RZ400 Mental healing
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Pharmacy > Department of Basic Medical Sciences Kulliyyah of Pharmacy
Depositing User:	Dr Muhammad Hakimi Mohd Rashid
Date Deposited:	03 Sep 2024 14:25
Last Modified:	03 Sep 2024 14:34
URI:	http://irep.iium.edu.my/id/eprint/114208

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