A review on Mitragyna speciosa (Rubiaceae) as a prominent medicinal plant based on ethnobotany, phytochemistry and pharmacological activities

Taslima Begum, Taslima and Arzmi, Mohd Hafiz and Khatib, Alfi and Helal Uddin, A.B.M. and Abdullah, Maryam Aisyah and Rullah, Kamal and Mat So'ad, Siti Zaiton and Haspi, Nur Fatihah Zulaikha and Sarian, Murni Nazira and Parveen, Humaira and Mukhtar, Sayeed and Ahmed, Qamar Uddin (2024) A review on Mitragyna speciosa (Rubiaceae) as a prominent medicinal plant based on ethnobotany, phytochemistry and pharmacological activities. Natural Product Research. pp. 1-17. ISSN 1478-6419 E-ISSN 1478-6427

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Abstract

Mitragyna speciosa Korth (kratom) is a tropical indigenous tree of Southeast Asia. It is commonly consumed by the people due to its various pharmacological properties. The leaves of this plant are traditionally used for the treatment of several diseases including pain, fever, cough, anxiety, depression, obesity, diarrhoea, wound healing, diabetes, hypertension as well as for the prevention of cancer and improvement of sexual performance. Phytochemical investigations have confirmed the presence of more than forty alkaloids along with the presence of other bioactive secondary metabolites. Among the alkaloids isolated, mitragynine and 7-hydroxymitragynine along with their derivatives have been widely evaluated and reported to possess various pharmacological effects. Hence, the aim of this review is to shed light on the traditional uses of kratom and the scientific studies to justify the folkloric claims and active principles responsible for the various medicinal effects associated with the leaves of this plant. This review highlights the potential benefits and toxicities associated with M. speciosa leaves along with the phytochemistry. Moreover, the existing gaps in the field of M. speciosa study have been identified along with the future directions to further avail the benefits of this plant species.

Item Type:	Article (Journal)
Uncontrolled Keywords:	Mitragyna speciosa; mitragynine; traditional uses; pharmacological effects; phytochemistry; analgesic
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Dentistry > Department of Fundamental Dental and Medical Sciences Kulliyyah of Dentistry Kulliyyah of Pharmacy Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Depositing User:	AP Ts Dr Mohd Hafiz Arzmi
Date Deposited:	30 Sep 2024 08:43
Last Modified:	30 Sep 2024 08:59
URI:	http://irep.iium.edu.my/id/eprint/113905

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