Putri, Megananda Hiranya and Nurjanah, Neneng and Laela, Dewi Sodja and Sukmasari, Susi (2024) Protective effects of mouthwash formulations of syzygium polyantha (L.) and piper betel (L.) on oral microbiota-induced gingivitis. Healthcare in Low-Resource Settings, 12 (1). pp. 1-6. E-ISSN 2281-7824
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Abstract
Using a combination of natural ingredients as a mouthwash was expected to have a synergistic effect in preventing gingivitis, a common oral disease. The objective of this study was to elucidate the anti-inflammatory effect of different proportions of mouthwash infusions: F1 (75% Syzygium polyantha and 25% Piper betle) and F2 (25% Syzygium polyantha and 75% Piper betle) on oral microbiota causing gingivitis. Twenty-four Rattus norvegicus were divided into four groups, and bacteria were injected into the periodontal sulcus. The anti-inflammatory effect was assessed by calculating the reduced number of polymorphonuclear (PMN) leukocytes. A cytotoxicity test was carried out on the normal fibroblast cell line 3T3-L1. There were no significant differences in the decreased number of PMN leukocytes (p = 0.079 > 0.05). Both F1 and F2 showed results of cell viability approaching 100% of living cells at concentrations of 0.29 ppm and 0.04 ppm, equivalent to 0.058% and 0.029%, respectively. This study concluded that both formulations of Syzygium polyantha and Piper betle have potential effects on gingivitis prevention. They had an effectiveness level almost similar to Chlorhexidine gluconate 2%. The toxicity value of formulation F1 is superior to that of formulation F2. Further studies concerning the toxicity of the mixtures and their effect on oral biofilm are needed.
| Item Type: | Article (Journal) |
|---|---|
| Uncontrolled Keywords: | mouthwash formulations, Syzigium polyanta leaves, Piper betle leaves, anti-inflammation, gingivitis |
| Subjects: | Q Science > QR Microbiology R Medicine > RK Dentistry R Medicine > RK Dentistry > RK318 Oral and Dental Medicine. Pathology. Diseases-Therapeutics-General Works |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Dentistry Kulliyyah of Dentistry > Department of Paediatric Dentistry and Dental Public Health |
| Depositing User: | Dr. Susi Sukmasari |
| Date Deposited: | 13 Aug 2024 10:01 |
| Last Modified: | 13 Aug 2024 10:31 |
| URI: | http://irep.iium.edu.my/id/eprint/113847 |
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