Correlation of tear osmolarity with ocular symptoms and ocular surface parameters in dry eye disease: a systematic review and meta-analysis

Md Mustafa, Md Muziman Syah and Abdul Muluk, Syaidatul Dianah and Muhd Helmi, Muhd Alwi (2024) Correlation of tear osmolarity with ocular symptoms and ocular surface parameters in dry eye disease: a systematic review and meta-analysis. Malaysian Journal of Medicine and Health Science, 20 (6). pp. 295-308. ISSN 1675-8544

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Abstract

Introduction: This systematic review and meta-analysis aimed to assess the correlations of tear osmolarity (TO) with ocular symptoms and ocular surface parameters in dry eye disease (DED). Materials and methods: A literature search was conducted in PubMed, ScienceDirect, and Google Scholar databases up to 31 December 2022. Observational studies were included if they reported Pearson’s-r or Spearman’s-ρ of TO with ocular symptoms and/or ocular surface parameter(s) in DED patients without or with other underlying diseases. The r or ρ values were extracted and assessed using a random effect of meta-analysis. Results: Twelve studies were included in the qualitative synthesis and meta-analysis. Overall weighted summary-r values amounted to 0.17, -0.35, and -0.29 for the correlations of TO with ocular symptoms, fluorescein break-up time (FBUT), and Schirmer I, respectively. In the DED subgroup, the weighted summary-r values amounted to 0.11, -0.32, and -0.12 for the correlations of TO with ocular symptoms, FBUT, and Schirmer I, respectively. Greater weighted summary-r values were found in the autoimmune disease-related DED (AID-DED) subgroup for the correlations of TO with ocular symptoms (weighted summary-r, 0.38), FBUT (weighted summary-r, -0.39), Schirmer I (weighted summary-r, -0.47), and corneal staining (weighted summary-r, 0.38). The I2 values were 36% to 92.4%. Conclusion: This systematic review and meta-analysis reveal weak to fair correlations between TO and clinical parameters in DED, with stronger correlations in AID-DED. The findings underscore the need for standardised diagnostic methods and further research to explore the distinct mechanisms of AID-DED. Future studies should focus on longitudinal assessments, advanced diagnostic tools, and patient-centred outcomes to enhance understanding and management of DED, ultimately informing clinical guidelines and improving patient care

Item Type:	Article (Case Report)
Uncontrolled Keywords:	Correlation, Dry eye disease, Ocular symptoms, Ocular surface parameters, Tear osmolarity
Subjects:	R Medicine > RE Ophthalmology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Allied Health Sciences > Department of Optometry and Visual Science Kulliyyah of Medicine Kulliyyah of Medicine > Department of Paediatrics
Depositing User:	AP Dr Md Muziman Syah Md Mustafa
Date Deposited:	16 Aug 2024 15:49
Last Modified:	10 Jan 2025 11:16
URI:	http://irep.iium.edu.my/id/eprint/113484

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