Serum interleukin 1β in patients with acquired laryngotracheal stenosis

Azwal, Norazwani and Lokanathan, Yogeswaran and Azman, Mawaddah and Ng, Min Hwei and Mohamed, Abdullah Sani and Mat Baki, Marina (2022) Serum interleukin 1β in patients with acquired laryngotracheal stenosis. Acta otorhinolaryngologica italica, 42 (3). pp. 250-256. ISSN 0392100X

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Abstract

Objectives. To determine the serum levels of interleukin-1beta (IL-1) in patients with acquired laryngotracheal stenosis (ALTS) and healthy volunteers and compare levels between serum and tissue of the stenotic segment. Materials and methods. An exploratory cohort study included 20 participants with ALTS and 5 healthy volunteers. ALTS group was categorised into mild and severe according to grade of stenosis and presence of tracheostomy. Comparisons of serum levels of IL-1 between pre- and post-surgical intervention and between blood and tissue samples in the severe ALTS group were made. Correlation of IL-1 levels between blood and tissue was assessed using Spearman’s correlation. Results. Severe ALTS patients showed higher serum levels of IL-1 compared to mild ALTS and healthy volunteers (p = 0.045). IL-1 was higher before surgical intervention than after surgical intervention (p = 0.003). There was a strong positive correlation of IL-1 between serum and tissue (r = 0.74, p = 0.035). Conclusion. Serum levels of IL-1 are higher in ALTS patients than in healthy controls and positively correlate with tissue levels. The decreasing trend of serum IL-1 observed following successful surgical intervention reflects the absence of ongoing inflammation at the stenotic segment.

Item Type:	Article (Journal)
Uncontrolled Keywords:	acquired laryngotracheal stenosis, interleukin-1beta, laryngeal stenosis, subglottic stenosis, inflammatory mediators
Subjects:	R Medicine > RF Otorhinolaryngology
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine Kulliyyah of Medicine > Department of Otolaryngology - Head and Neck Surgery
Depositing User:	Dr Norazwani Azwal
Date Deposited:	14 Jan 2025 08:44
Last Modified:	14 Jan 2025 08:44
URI:	http://irep.iium.edu.my/id/eprint/113332

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