Mohamad Amri, Nur Fathonah and Abd. Rahim, Nour El Huda and Zulkifly, Ahmad Hafiz and Hassan, Habibah and Mohd Jan, Nurul Hafiza and Ibrahim, Mohd Zulfadzli (2024) Therapeutic potential of Tualang honey formulation in osteoarthritis: a comparative study in New Zealand white rabbit models. Malaysian Orthopaedic Journal, 17 (Suppl. A). ISSN 1985-2533 E-ISSN 2232-111X
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Abstract
INTRODUCTION: Osteoarthritis (OA) is a prevalent degenerative joint disease with significant global impact. Honey has shown therapeutic potential in treating OA1. This study aims to evaluate the therapeutic potential of Tualang Honey Formulation (THF) in the management of OA using a New Zealand White Rabbit (NZWR) model, in comparison to the control group. MATERIALS & METHODS: A controlled experiment was conducted with sixteen NZWR, surgically induced to develop OA. The experimental group received THF intraarticularly after 3 weeks post-surgery, while control group did not receive any treatment. The rabbits were then euthanized and x-rays were taken at 3, 6, 12, and 24 weeks to evaluate joint space narrowing and subchondral sclerosis as indicators of OA progression. RESULTS: Radiographic analysis showed that rabbits treated with THF exhibited less joint space narrowing and subchondral sclerosis compared to the control group. Notable radiological improvements were evident from the 6-week mark, indicating a slower progression of OA. DISCUSSIONS: THF appears to improve the radiographic progression of OA, suggesting its potential as a therapeutic agent2. Its effects on subchondral sclerosis and joint space preservation suggest its beneficial effects on joint health. CONCLUSION: THF demonstrates radiographic and potential benefits in OA management in NZWR. Further research is warranted to understand its therapeutic mechanisms.
| Item Type: | Article (Abstract) |
|---|---|
| Uncontrolled Keywords: | Tualang Honey, Osteoarthritis, New Zealand White Rabbits |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RD Surgery R Medicine > RD Surgery > RD701 Orthopedics |
| Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): | Kulliyyah of Medicine Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Department of Orthopaedics, Traumatology & Rehabilitation |
| Depositing User: | Dr Nour El Huda Abd Rahim |
| Date Deposited: | 03 Dec 2024 12:13 |
| Last Modified: | 04 Dec 2024 08:00 |
| URI: | http://irep.iium.edu.my/id/eprint/113205 |
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