Production of autologous platelet-rich plasma from an animal model

Buyong, Zunariah and A.Talib, Norlelawati and Ab Rahman, Jamalludin and Khalid, Kamarul Ariffin and Zakaria@Mohamad, Zamzuri and Zulkifly, Ahmad Hafiz and Abdel Wahab, Emad Mohamad Nafie (2010) Production of autologous platelet-rich plasma from an animal model. In: IIUM Research, Invention and Innovation Exhibition 2010, 26-27th January 2010, CAC. (Unpublished)

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Abstract

There has been recent interest regarding the role of autologous platelet-rich plasma (PRP) on soft and hard tissue healing. Inactivated platelets contain various growth hormones that involve in tissue healing such as platelet-derived growth hormone (PDGF), vascular ndothelial growth hormone (VEGF), transforming growth factor-ß (TGF-ß), epidermal growth factor (EGF) and insulin-like growth factor (IGF). Upon activation, platelets release these hormones from its α-granule. PRP concentration of three to five-fold the baseline level or the count above 1,000,000/ml was shown the ability to promote tissue healing. Even though the protocol for the production of PRP from a large amount of blood has been established in human, the method could not be adopted in animal studies, which require small amount of blood. Lack of method’s standardization in PRP preparation has also contributed to the difficulty of getting sufficient PRP for experimental studies. Here, we presented a double-centrifugation technique for the production of autologous PRP from rabbit’s blood.

Item Type:	Conference or Workshop Item (Poster)
Additional Information:	5178/11276
Subjects:	R Medicine > R Medicine (General)
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button):	Kulliyyah of Medicine > Department of Basic Medical Kulliyyah of Medicine > Department of Community Medicine (Effective: 1st January 2011)
Depositing User:	DR ZUNARIAH BUYONG
Date Deposited:	19 Dec 2011 17:35
Last Modified:	10 Mar 2016 15:02
URI:	http://irep.iium.edu.my/id/eprint/11276

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